therapy resistant hypertension in renal transplant recipients
Conditions
Interventions
Intervention: All patients will continue to receive usual antihypertensive
treatment according to prevailing guidelines. Percutaneous renal denervation of
the native kidneys will be performed at the
hypertension
kidney transplantation
renal denervation
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Age 18-75 years - First kidney transplant in situ >6 months prior to randomization - Urine measured creatinine clearance * 30 ml/min - Radiological evidence for residual flow in the renal arteries indicating that they are accessible for the intervention - Mean day-time systolic blood pressure of at least 135 mmHg (using ambulatory blood pressure monitoring) despite the use of at least 3 antihypertensive drugs, or with documented intolerance or contraindication for to 2 or more of the 4 major classes of antihypertensive drugs (ACEi/ARB, calcium channel blockers, betablockers and diuretics) thus being unable to be treated with 3 antihypertensives. - Hemodynamically significant stenosis of the renal artery of the graft as a cause of therapy resistant hypertension has to be (have been) excluded (using MRI).
Exclusion criteria
Exclusion criteria: - (Planned) pregnancy, lactation - Life expectancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study parameters/endpoints: Primary endpoint is the change in blood pressure after 6 months (mean day time systolic blood pressure assessed by 24-hour ambulatory measurement). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes include changes in office blood pressure, changes in antihypertensive treatment, plasma catecholamines, renin and aldosterone, eGFR and 24h proteinuria, Moreover, compliance with antihypertensive treatment compliance will be measured using a questionnaire and by detection of antihypertensives in a blood sample. | — |
Countries
The Netherlands
Outcome results
None listed