acute kidney injury renal dysfunction
Conditions
Interventions
Patients will be randomly allocated to the Control or the GDP group.
Randomization will be performed locally at each participating Institution,
using computer-generated schemes. The patients in cont
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Adult patients Patients undergoing cardiac surgery with expected bypass time of 90 minutes or longer
Exclusion criteria
Exclusion criteria: severe chronic renal failure moderate-severe anemia (hematocriet
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of AKI, defined according to the AKIN criteria (9) as: AKI stage 1: peak postoperative serum creatinine > 1.5 x baseline, within the first 48 hours after surgery. AKI stage 2: peak postoperative serum creatinine > 2.0 x baseline, within the first 48 hours after surgery (AKI stage 3 will be incorporated in the AKI stage 2 group). Any AKI: stage 1 or higher Peak serum creatinine: within the first 48 postoperative hours. Diagnosis of AKI must be reached within the first 48 hours after surgery, but staging may require a longer time (up to 7 days after surgery). | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of ICU stay (days) Transfusion (PRCs) rate and amount of PRCs units transfused Major morbidity (according to STS): mechanical ventilation > 48 hours, AKI stage 2, surgical revision, mediastinitis, stroke. Operative (in-hospital) mortality | — |
Countries
Netherlands
Outcome results
None listed