Developing diagnostic criteria for the differentiation between large vessel vasculitis and atherosclerosis using 18FDG-PET/CT

Developing diagnostic criteria for the differentiation between large vessel vasculitis and atherosclerosis using 18FDG-PET/CT - Vasculitis or Atherosclerosis on 18FDG-PET/CT / VAPC

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON42061

Enrollment

Registered

2014-09-10

Start date

2015-02-10

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

atherosclerose (bloedvataandoeningen) blood vessel calcification blood vessel inflammation

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Group I: Patients with biopsy-proven giant cell arteritis with any type/degree of large-artery 18-FDG-uptake in the absence of clues pointing to severe atherosclerosis (history of cardiovascular disease or a >2-fold increased age-adjusted CVD risk. Patient scans will be retrieved from our database.;Group II: Patients with severe atherosclerosis affecting at least the thoracic and/or abdominal- iliacal aorta and any type/degree of large-artery 18-FDG uptake. Patients >50 years of age with manifest atherosclerotic disease will be selected from the vascular surgery outpatient clinic.

Exclusion criteria

Exclusion criteria: Group I: Use of immunosuppressive drugs Known cancer Reluctance or inability to provide informed consent;Exclusion criteria for group II: ESR >30 mmHg and/or CRP >10 mg/l Myalgia in shoulder/pelvic regions (suggestive of PMR) History of vasculitis or other type of systemic auto-immune disease Use of immunosuppressive drugs Reluctance or inability to provide informed consent

Design outcomes

Primary

Measure	Time frame
We anticipate that criteria relating to 18-FDG uptake distribution and intensity, and presence of calcium deposits on low-dose CT, will differentiate between vasculitis and atherosclerosis.	—

Countries

Netherlands

Outcome results