gezonde veroudering healthy aging old age
Conditions
Interventions
Subjects will receive either 150 mg/kg body weight tyrosine or 50 mg/kg body
weight Fantomalt diet carbohydrate powder mixed with 100 mg/kg cornstarch
(placebo condition), in both cases dissolved in
Sponsors
Radboud Universiteit Nijmegen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria (zie sectie 4.2 op pagina 12 van het protocol) In order to be eligible to participate in this study, subjects must meet all of these criteria: - Age: 60-75 years old - Proficient knowledge of the Dutch language - Right-handed - Willing to perform tasks in the MRI scanner, to come to the centre on three occasions, consuming tyrosine or a placebo and willing to fast the night before the two test sessions.
Exclusion criteria
Exclusion criteria: Exclusion criteria (see section 4.3 on page 12 of the protocol) A potential subject who meets any of the following criteria will be excluded from participation in this study (for a checklist see F1 Intake Questionnaires and Checklists): - Mini Mental State Examination score 11 - Estimated IQ
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We will assess the effect of the intervention on BOLD signal measured with functional magnetic resonance imaging (fMRI) and response times and accuracy on the computerized tasks during fMRI. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondarily, effects on paper and pencil neuropsychological tasks will be assessed. Also, intervention effects on subjective measurements (e.g. self-report questionnaires, visual analogue scales), on catecholamine and serotonin metabolites (MVA - metanefrine, HVA - normetinefrine, HVA - 3-MT and 5-HIAA) in urine samples, and on physiological recordings (blood pressure, heart rate) will be measured. | — |
Countries
Netherlands
Outcome results
None listed