psychological Neurofibromatosis type 1 and tuberous sclerosis complex (NF1 and TSC)
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
2 Years to 99 Years
Inclusion criteria
Inclusion criteria: Participants are part of a monozygotic twin pair (which is genetically confirmed), disease genetically confirmed (either NF1 or TSC1/TSC2 mutation), oral and written informed consent by participants older than 18 years old, and oral and written informed consent by both caregivers of children below 18 years old and assent by participants between 12 and 18 years old.
Exclusion criteria
Exclusion criteria: A potential subjects of whom the twin sibling is not willing or able to participate in this study, will be excluded from participation in this study Symptomatic brain pathology
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The difference in correlation of full IQ between twin pairs with either NF1 or TSC and healthy twins in the population. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures are the difference in correlation of word-reading ability and attention problems between twin pairs with either NF1 or TSC and unaffected twins in the general population. Tertiary outcome measures are the correlations of visuospatial judgement and behavioural problems in patients with NF1 and TSC. | — |
Countries
Netherlands
Outcome results
None listed