transposition of the great arteries
Conditions
Interventions
aorta hemodynamics
blood flow
magnetic resonance imaging
transposition of great vessels
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
2 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Patients with surgical repair for transposition of the great arteries (TGA) through arterial switch operation. - Patients operated in the LUMC with clinical follow-up in the CAHAL (Center for Congenital Heart Disease Amsterdam-Leiden) are eligible for inclusion. - Patients older than 8 years of age. - Healthy volunteers older than 12 years of age.
Exclusion criteria
Exclusion criteria: Patients with pre-existing arch anomalies at presentation (e.g. aortic coarctation, hypoplastic aortic arch, aortic arch interruption) or those who had undergone a two-stage repair (e.g. previous pulmonary arterial banding before second-stage ASO) will be excluded from inclusion. Patients with claustrophobia, mental retardation, pacemaker dependency, will not be included in this study. Excluding factors will be: diagnosis of a chronic disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. measurements 2D large vessels: - LV-ascending aorta outflow angle - aortic arch angle, - volume aortic sinus - aortic wall thickness at predefined anatomical landmarks in the thoracic aorta - pulmonary artery dimensions (at level of neoaortic root) 2. measurements 4D flow large vessels: - qualitative: o identify complex flow patterns, viewed dynamically in 3D: discriminate helix and vortex flow patterns and localisation of these patterns in the aorta - flow quantification: o symmetry/asymmetry of (peak) bloodstream profiles in ascending aorta and pulmonary arteries o peak systolic regional wall shear stress at predefined anatomical landmarks in the thoracic aorta o 3D pressure difference maps o turbulent kinetic energy, energy loss 3. measurements of cardiac function: - end-systolic left ventricle volume - end-diastolic left ventricle volume - ejection fraction left ventricle - regional wall motion disturbances 4. measurements of aerobic fitness: - oxygen uptake (ml/kg/min) - peak power in last half minute of graded bicycle ergometer test (Watt) 5. Impedance cardiography parameters: - estimated stroke volume - cardiac autonomic control measures | — |
Secondary
| Measure | Time frame |
|---|---|
| None | — |
Countries
The Netherlands
Outcome results
None listed