obesitas diabetes metabolic diseases
Conditions
Interventions
All subjects will receive five interventions in an order randomized within
drinks and muffins. The food products will be consumed in fasting state as a
breakfast 1) Control drink, a fruit-based drin
2) Xylose drink, a fruit-based
drink with added xylose (xylose added as 10 wt% of sugar)
3) Arabinose drink,
a fruit-based drink with added arabinose (arabinose added as 10 wt% of sugar)
4) Control muffin
5) Arabinose muffin, a muffin with added arabinose
(arabinose added as 10 wt% of sugar).
Sponsors
Cosun Biobased Products
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Male • 18-35 Years old while signing the informed consent • Good Dutch speaking, writing, understanding • Healthy: as judged by the subject • BMI: 18.5-25 kg/m2 • Stable body weight, i.e. no reported weight loss or weight gain of > 5 kg in the two months prior to the screening session • Normal fasting glucose concentration 8.5 mmol/L
Exclusion criteria
Exclusion criteria: • Allergy, intolerance or oversensitivity for the food products under study • Having a history of medical or surgical events that may affect the study outcome • Having reported gastro-intestinal problems • Medical drug use that may affect the study outcome • Current antibiotics usage or in the two months prior to the screening session • Not willing to eat muffins or to drink fruit-based drinks • Being a vegetarian (not willing to eat meat) • Use of dietary supplements that may affect the study outcome • Currently using a slimming or medically prescribed diet or having used one in the two months prior to the screening session • Excessive alcohol consumption (>21 glasses/week on average) • Mental status that is incompatible with the proper conduct of the study • Elite athletes, i.e. exercise > 7h/week vigorously • Planning to change physical activity pattern during the study period • Having blood vessels that are too difficult for inserting a cannula, as judged by the study nurse • Recent blood donation (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The glycaemic response, measured as AUC of plasma glucose during 180 minutes. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) The insulin response, measured as AUC of plasma insulin during 180 minutes. 2) The recovery of stable isotope in breath as a marker for sucrose metabolisation during 180 minutes. 3) Ad libitum energy intake, measured as lunch after 240 minutes. 4) Appetite, measured using a VAS-questionnaire during 300 minutes. 5) Gastro-intestinal comfort using a questionnaire. 6) Study diary. | — |
Countries
Netherlands
Outcome results
None listed