adrenal insufficiency
Conditions
Interventions
an ACTH stimulation test, cortisol measurements in blood and hair.
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Receive a treatment for HIV-infection - > 18 years old - Current usage of inhalation or nasal corticosteroids - Willing to give informed consent
Exclusion criteria
Exclusion criteria: - Known adrenal insufficiency - Concurrent use of topical corticosteroids, usage of oral corticosteroids in the last three months. Intramuscular or intra-articular corticosteroid injections in the last year. - Contra-indications for tetracosactide: allergy for tetracosactide, Cushings*s syndrome, refractory heart failure, peptic ulcer, acute psychosis, adrenogenital syndrome - Pregnant female or breast-feeding female. - Use of oral contraceptives, since these can heighten the cortisol-binding globulin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportions of persons with a low morning plasma cortisol or low cortisol after an ACTH stimulation test. | — |
Secondary
| Measure | Time frame |
|---|---|
| b. Proportions of persons with a low morning plasma cortisol or low cortisol after an ACTH stimulation test, stratified e.g. by kind of inhalation corticosteroid, dosage of local corticosteroid and use/no use of CYp3A4 inhibitor. c. Correlation between cortisol in plasma and hair cortisol. | — |
Countries
Netherlands
Outcome results
None listed