Diabetes
Conditions
Interventions
Stopping metformin use 24 hours preoperatively.
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Signed informed consent Aged 18-80 years Scheduled for elective non-cardiac surgery Known diabetes mellitus type 2 for > 3 months Using metformin > 3 months
Exclusion criteria
Exclusion criteria: Insulin use Planned day case/outpatient surgery Planned OR-duration * 45 min Planned ICU stay post-operatively Existing severe liver disease or alcohol abuse Known renal function impairment Planned corticosteroid treatment perioperatively Females of child bearing potential who are pregnant, breast-feeding or intend to become pregnant or are not using adequate contraceptive methods (adequate contraceptive measures as required by local law or practice) Any condition that the local investigator feels would interfere with trial participation or the evaluation of results
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The difference in postoperative glucose values 2 hours after surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| The difference in fasting glucose values at day 1 after surgery. The difference in lactate levels 2 hours after surgery and at day 1 after surgery. The difference in the amount of insulin administered during surgery. The occurrence of mild and severe hypoglycaemia (glucose | — |
Countries
Netherlands
Outcome results
None listed