Multicenter Aggression subTyping Research in Conduct Syndromes: An exploratory study

Multicenter Aggression subTyping Research in Conduct Syndromes: An exploratory study - MATRICS

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON41946

Enrollment

Registered

2015-04-30

Start date

2016-04-22

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

conduct disorder

Interventions

None listed

Eligibility

Age

2 Years to 17 Years

Inclusion criteria

Inclusion criteria: age 8 - 18 IQ > 80;for the patient group: diagnosis of ODD/CD aggression in the clinical range

Exclusion criteria

Exclusion criteria: IQ

Design outcomes

Primary

Measure	Time frame
Scores on questionnaires about CU traits, aggression and conduct problems are the independent variables in this study. The main outcome measures are (1) performance on tasks of emotion recognition, impulsivity and memory (2) volume size of prefrontal and limbic brain regions, white matter integrity, functional network connectivity, and brain activation during a face matching task, passive avoidance task and stop signal task (3) anterior cingulate and striatal glutamate concentration and (4) aggression related genotypes as well as hormone levels.	—

Measure

Time frame

Scores on questionnaires about CU traits, aggression and conduct problems are the independent variables in this study. The main outcome measures are (1) performance on tasks of emotion recognition, impulsivity and memory (2) volume size of prefrontal and limbic brain regions, white matter integrity, functional network connectivity, and brain activation during a face matching task, passive avoidance task and stop signal task (3) anterior cingulate and striatal glutamate concentration and (4) aggression related genotypes as well as hormone levels.

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Secondary

Measure	Time frame
Additional measures include hair cells to be reprogrammed into human induced pluripotent stem cells (hiPSCs) and optionally, a stool sample to investigate the human microbiome (bacteriome). The stool samples will be collected at a later time from participants that give consent for this extra part of the study.	—

Countries

Netherlands

Outcome results