sporadic advanced colorectal adenoma sporadic high-risk colorectal polyps
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - >45 years - scheduled for screening colonoscopy or subsequent polypectomy. Indications for screening colonoscopy are rectal blood loss, anemia, change in bowel habits, positive iFOBT or positive family history of adenomas or CRC (two or more first degree relatives or one or more at age 50 years or less).
Exclusion criteria
Exclusion criteria: - having hereditary colorectal cancer syndrome (e.g. Lynch syndrome or polyposis syndromes) or suspicion thereof - having inflammatory bowel disease - previous adenoma - cancer within the past five years - colonoscopy that is incomplete or associated with a poor preparation - lack of histological classification of polyps removed at screening colonoscopy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in DNA methylation of a certain adenoma subtype and normal mucosa of controls. Difference in cfDNA methylation of screening colonoscopy patients with advanced adenoma and those found to be free of colorectal polyps/cancer and inflammation. . | — |
Secondary
| Measure | Time frame |
|---|---|
| Difference in DNA methylation of a certain adenoma subtype and leucocytes of controls, (pre)malignant tissue from cancer other than CRC or inflammatory conditions, or non-advanced polyps. Difference in cfDNA methylation of screening colonoscopy patients with advanced adenoma and those with non-advanced polyps. | — |
Countries
Netherlands
Outcome results
None listed