Effects of Obstructive Sleep Apnea Treatment On Opioid-Induced Respiratory Depression

Effects of Obstructive Sleep Apnea Treatment On Opioid-Induced Respiratory Depression - OSAS study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON41933

Enrollment

Registered

2015-08-21

Start date

2016-03-29

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pijnsysteem Obstructive Sleep Apnea

Interventions

Intervention: patients accepted for bariatric surgery meeting all inclusion criteria and none of the exclusion criteria will be enrolled in the study, after informed consent is obtained. First, the

normal PG

AHI5

PG proven moderate-severe OSA

AHI>15) will be enrolled in group 2. All study patients will be subjected to a pain threshold study and respiratory study (paragraph 3.2). Thereafter, bariatric surgery will be performed in group 1

OSAS

remifentanil

respiratory depression

sleep apnea

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: • age older than 18 years • patients selected for bariatric surgery • confirmed non-OSA (AHI=15) by PG for group CPAP and Surgery

Exclusion criteria

Exclusion criteria: • age younger than 18 years • CPAP treatment before the start of the study • patients with a *worst pain* >5 on the BPI • patients with PSG result indicating mild OSA (AHI >= 5 and

Design outcomes

Primary

Measure	Time frame
Minute ventilation (Vi) (L/min; % change) Tidal Volume (Vt) (ml; % change) End-tidal pCO2 (kPa; % change) Respiratory Rate (RR) (% change) SpO2 (%; % change)	—

Secondary

Measure	Time frame
Electrical Pain Detection Threshold (mA) Conditioned Pain Modulation (% EPDT)	—

Countries

The Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)