effects of nerve blockade on the kidney function
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - age *18 years - able to give informed consent - no recent changes or expected changes in antihypertensive medications or psychopharmaca - we aim at including at least 50% of the patients with an eGFR 60ml/min: the patients with the lowest eGFRs will be selected for inclusion.
Exclusion criteria
Exclusion criteria: - not willing to be informed about unexpected findings during the study - neurologic disease - Lung disease - pregnancy - renal replacement therapy (hemo- or peritoneal dialysis) - iodine allergy - allergy for shellfish - not being able to resign from cigarette smoking/ nicotine use in any form, for >20 hours ;PLEASE NOTE: the second GFR and RPF measurements will only be performed in patients with a successful persistent blockade that has been clinically assessed by the pain specialist. In the case of LSB: treatment is regarded as successful upon vasodilatation and in the case of splanchnic blockade relief of pain.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary Objective: to assess the effects of lumbar sympathetic blockade on glomerular filtration rate (GFR) and renal plasma flow (RPF) by studying the differences in measured GFR (in ml/min) and the difference in measured ERPF (in ml/min) before and after lumbar sympathetic blockade or splanchnic blockade in patients with a clinically assessed effective permanent blockade. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary Objective(s): to assess the differences before and after effective lumbar sympathetic blockade or splanchnic blockade in daytime office based blood pressure and systemic haemodynamics (non-invasive estimations of stroke volume, cardiac output, systemic vascular resistance and pulse wave velocity) | — |
Countries
Netherlands
Outcome results
None listed