Functional magnetic resonance imaging of human hypothalamic responses to oral glucose ingestion in obese and lean subjects

Functional magnetic resonance imaging of human hypothalamic responses to oral glucose ingestion in obese and lean subjects - HYROB (HYpothalamic Response to oral glucose ingestion in OBesity)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON41891

Enrollment

Registered

2015-01-28

Start date

2014-12-01

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

corpulence Obesity

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: BMI >30 for obese subjects and BMI 19-25 for lean subjects Age 21-30 years Male

Exclusion criteria

Exclusion criteria: History of diabetes or medication influencing glucose metabolism Relevant genetic or psychiatric disease Chronic disease Renal or hepatic disease Recent weight loss > 5 kg within the last 3 months Smoking Alcohol consumption > 21 units per week Use of recreational drugs during the last year Recent blood donation (

Design outcomes

Primary

Measure	Time frame
BOLD signal intensity changes of the hypothalamus after ingestion of 2 different stimuli (300 ml each): water at room temperature and glucose solution at room temperature. The last stimulus will contain 75g of glucose.	—

Secondary

Measure	Time frame
BOLD responses in amygdala and nucleus accumbens Z-scores of functional connectivity (rs-fMRI) Psychophysical ratings of hunger and pleasantness of taste scored by VAS	—

Countries

Netherlands

Outcome results