The effect of L-arginine on brown adipose tissue metabolism in South Asian and white Caucasian subjects

The effect of L-arginine on brown adipose tissue metabolism in South Asian and white Caucasian subjects - The effect of L-arginine on brown adipose tissue activity

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON41875

Enrollment

Registered

2014-09-09

Start date

2015-10-09

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

overweight

Interventions

L-arginine (9 gram/day) and placebo. The study has a cross-over design and is furthermore double blind. That means that the subject will first receive one of these interventions for 6 weeks, followe

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Caucasians and South Asians ethnicity - Age: 35-50 years - Gender: male - BMI: 25-30 kg/m2 - Plasma glucose levels 2 h after OGTT between 7.8 and 11 mM (e.g. impaired glucose tolerance) or Fasting plasma glucose > 5.5 mM - Good general health

Exclusion criteria

Exclusion criteria: - Type 2 diabetes (determined on basis of oral glucose tolerance test (OGTT)) - BMI > 30 kg/m2 - Plasma glucose levels 2 h after OGTT 100 *mol/L - Participation in earlier research or medical examinations that included PET-CT scanning - Psychologically unstable subjects (as judged by the treating medical specialist) - Subjects with mental retardation (as judged by the treating medical specialist) - Subjects with severe behavior disorders (as judged by the treating medical specialist) - Contra-indications MRI (facultative): presence of metallic objects in which the magnetic field can disrupt its function, including pacemaker, insulin pump, neurostimulator, vascular clips, interior hearing device and artificial cardiac valves. Additionally, we will exclude subjects with metallic residues in the eye (posttraumatic), large tattoos and orthopaedic protheses in the field of the camera.

Design outcomes

Primary

Measure	Time frame
1) glucose uptake by brown adipose tissue 2) energy expenditure 3) fat mass	—

Secondary

Measure	Time frame
1) Thermoregulation (skin temperature, core temperature, skin perfusion and endothelium-dependent and -independent vasodilation) and endothelial function 2) Plasma lipids and glucose tolerance 3) Systemic inflammation and adipose tissue inflammation 4) Insulin signaling in muscle	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)