Brain injury
Conditions
Interventions
Brain damage
Moderate preterm
Neonates
Sponsors
Isala Klinieken
Eligibility
Age
2 Years to 11 Years
Inclusion criteria
Inclusion criteria: 1. Born prematurely, gestational age 32-36 weeks; 2. Admission to the neonatal high care or medium care unit.
Exclusion criteria
Exclusion criteria: 1. Congenital malformations of the central nervous system; 2. Chromosomal disorders; 3. Inborn errors of metabolism; 4. Congenital infections; 5. Central nervous system infections; 6. Brain injury acquired after the neonatal period 7. Parents do not speak Dutch or English
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Presence/absence of brain injury on cUS at day 3 and/or 7 and/or on cUS and/or MRI at TEA (composite endpoint of all diagnostic modalities and time points). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Maternal factors 2. Intra-partum factors 3. Infant factors 4. Presence/absence of brain injury on cUS at day 3 5. Presence/absence of brain injury on cUS at day 7 6. Presence/absence of brain injury on cUS and/or MRI at TEA 7. Presence/absence of abnormal findings at neurological examination at TEA 8. Presence/absence of abnormal neurodevelopmental outcome at 2 years of age | — |
Countries
The Netherlands
Outcome results
None listed