Heart Attack Myocardial Infarction
Conditions
Interventions
None listed
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Individual is * 18 and * 85 years of age 2. Individual has evidence of ST-segment elevated myocardial infarction (ST elevation *2 mm in *2 contiguous leads in V1 through V5) for more than 30 minutes (case) 3. Individual has an anticipated time of symptom onset to reperfusion of *6 hours (case) 4. Individual has an indication for an invasive coronary angiogram. 5. Individual agrees and is competent and willing to provide written, informed consent to participate in this clinical study.
Exclusion criteria
Exclusion criteria: 1. Individual has signs and symptoms of septic shock 2. Individual has a history of urea cycle disorders in wich arginase deficiency is a key factor 3. Individual has a arginine/arginase-dependent malignancy, such as human hepatocellular carcinoma
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Arginase(ng/ml) will be determined by means of an enzyme-linkend immunosorbent assay (ELISA), its activity will be determined by measurement of arginine-, citruline- and ornithine (arginine metabolite) levels in plasma. | — |
Secondary
| Measure | Time frame |
|---|---|
| none | — |
Countries
Netherlands
Outcome results
None listed