Intra cellular oxygen measurement during photodynamic therapy

Intra cellular oxygen measurement during photodynamic therapy - PO2DT

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON41860

Enrollment

Registered

2015-06-22

Start date

2015-07-13

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Actinic keratosis basal cell carcinoma skin cancer solar keratosis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Undergo 5-aminolevulinic acid precursor photodynamic therapy

Exclusion criteria

Exclusion criteria: Less than 18 years of age

Design outcomes

Primary

Measure	Time frame
Intracellular oxygen availability	—

Secondary

Measure	Time frame
• Skin temperature at the lesion • Sensor temperature • Accuracy of cellular oxygen measurement (variation of repeated measurements with stable circumstances) • Minimum measured value, expected during local pressure on skin (expected to be less than 10 mmHg) • Maximum measured value, expected briefly after release of the pressure. In subjects with dense vascularization this is expected to rise to a value that is only slightly below the arterial oxygen tension (known to be about 100mmHg in healthy adults). Because of the measurement principle (mitoPO2 ~ 1/lifetime) larger variations are expected at higher oxygen tensions. • Oxygen consumption • PDT area size • Pain • Body weight • Body length • Body mass index • Smoking, drug, alcohol • Parameters influencing the microcirculation such as: Medication, vessel diseases, .. • Clinical efficacy of PDT treatment • Skin type	—

Measure

Time frame

• Skin temperature at the lesion • Sensor temperature • Accuracy of cellular oxygen measurement (variation of repeated measurements with stable circumstances) • Minimum measured value, expected during local pressure on skin (expected to be less than 10 mmHg) • Maximum measured value, expected briefly after release of the pressure. In subjects with dense vascularization this is expected to rise to a value that is only slightly below the arterial oxygen tension (known to be about 100mmHg in healthy adults). Because of the measurement principle (mitoPO2 ~ 1/lifetime) larger variations are expected at higher oxygen tensions. • Oxygen consumption • PDT area size • Pain • Body weight • Body length • Body mass index • Smoking, drug, alcohol • Parameters influencing the microcirculation such as: Medication, vessel diseases, .. • Clinical efficacy of PDT treatment • Skin type

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Countries

Netherlands

Outcome results