Increasing plasma adrenaline levels through breathing techniques - an explorative study

Increasing plasma adrenaline levels through breathing techniques - an explorative study - INADRI

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON41858

Enrollment

Registered

2014-11-27

Start date

2014-12-03

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

RA reumatoid arthritis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Age >=18 and

Exclusion criteria

Exclusion criteria: - Experience with the methods of Wim Hof and his team or other breathing techniques - Use of any medication - Smoking - Use of recreational drugs within 21 days prior to the experiment day - Use of caffeine or alcohol within 1 day prior to the experimental day. - Surgery or trauma with significant blood loss or blood donation within 3 months prior to the experimental day. - Participation in another clinical trial within 3 months prior to the experimental day. - History, signs, or symptoms of cardiovascular disease - History of atrial or ventricular arrhythmia - Hypertension (RR systolic >160 or RR diastolic >90) - Hypotension (RR systolic 20 mg/L, WBC > 12x109/L, or clinically significant acute illness, including infections, within 4 weeks before the experimental day.

Design outcomes

Primary

Measure	Time frame
The main study parameter is plasma adrenaline concentration. Our primary endpoint is the difference between plasma adrenaline levels during the hyper/hypoventilation technique and the strength ventilation technique within the HTR group.	—

Secondary

Measure	Time frame
- Difference between plasma adrenaline levels during the hyper/hypoventilation technique and plasma adrenaline levels during the strength ventilation technique within the EIN and SIN groups. - Differences in plasma adrenaline levels during hyper/hypoventilation or strength ventilation between HTR, EIN, and SIN groups. - Differences in the following parameters between hyper/hypoventilation and strength ventilation within HTR, EIN, and SIN groups as well as differences during hyper/hypoventilation or strength ventilation between HTR, EIN, and SIN groups. o Plasma IL-10 concentration o Body temperature o Hemodynamic parameters (heart rate, blood pressure) o Leukocyte counts and differentiation o Cortisol (hair and plasma) o Other catecholamine*s (including noradrenaline) o Heart rate variability o Blood gas parameters Pain thresholds before start training/instruction and at the end of the experimental day, objectified with Quantative Sensory Testing	—

Measure

Time frame

- Difference between plasma adrenaline levels during the hyper/hypoventilation technique and plasma adrenaline levels during the strength ventilation technique within the EIN and SIN groups. - Differences in plasma adrenaline levels during hyper/hypoventilation or strength ventilation between HTR, EIN, and SIN groups. - Differences in the following parameters between hyper/hypoventilation and strength ventilation within HTR, EIN, and SIN groups as well as differences during hyper/hypoventilation or strength ventilation between HTR, EIN, and SIN groups. o Plasma IL-10 concentration o Body temperature o Hemodynamic parameters (heart rate, blood pressure) o Leukocyte counts and differentiation o Cortisol (hair and plasma) o Other catecholamine*s (including noradrenaline) o Heart rate variability o Blood gas parameters Pain thresholds before start training/instruction and at the end of the experimental day, objectified with Quantative Sensory Testing

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Countries

Netherlands

Outcome results