epithelial ovarian cancer Epithelial ovarian carcinoma
Conditions
Interventions
During the planned surgery (regular treatment) a maximum of four samples of
peritoneum (4mm2 each) will be collected. Two peritoneal samples will contain
tumormaterial and two samples of peritoneum
Sponsors
Antoni van Leeuwenhoek Ziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Patients with serous ovarian cancer, FIGO stage III or IV, undergoing cytoreductive surgery or, 2. Patients undergoing abdominal surgery for a benign ovarian mass (control group)
Exclusion criteria
Exclusion criteria: Patients deprived from ability to decide for participation on her own During surgery, it appears, collection of samples is associated with additional health risk
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Structural investigation of the peritoneum by histology and immunostaining of peritoneal components in EOC. 2. Investigation of the peritoneal micro-environment in EOC, by measurement of the quantity and characteristics of MPs and exosomes, excreted by mesothelial cells, and by measurement of cytokines with anti-angiogenic or proliferation inhibiting functions. | — |
Countries
Netherlands
Outcome results
None listed