sleep deprivation and social jetlag sleep deprivation and circadian misalignment
Conditions
Interventions
Short wavelength (blue) light reducing orange glasses (blue light absorption
>93%
appendix D1b
experimental condition 1) for seven days for at least three
hours before sleep time (lights out
when waking up during the night, e.g. to
use the toilet, participants will be asked to put on the glasses before
switching on the room lights), and blue-LED-light emitting glasses
(www.enwake.me
comparable to the Philips goLITEblu devices
appendix D1c
experimental condition 2) for two hours after wake up. The order of
experimental glasses 1 and 2 will be randomized.
Sponsors
Rijksuniversiteit Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Healthy men and women between 18 and 45 years of age Social jetlag = difference between mid-sleep on workdays and days off of minimum 2 hours Written informed consent
Exclusion criteria
Exclusion criteria: • Sleep disorders, e.g. sleep apnoea, narcolepsy, restless legs, primary insomnia (will be asked in the General Questionnaire, appendix F1a) • Mood disorder; because of the possibility of depressive mood as co-morbidity in late chronotypes we will exclude depressed participants • Two or more time zones crossed 1 month before study participation • Shift-work during 5 years prior to participation • Recent eye surgery (last year), glaucoma or other eye disease • History of chronic diseases, and/or use of chronic medication for 3 months or longer before study participation • Alcohol/drug problems (based on answers to General Questionnaire, appendix F1a) • The use of photosensitizing medication • Wearing spectacles already (contact lenses allowed) • Sleeping with open curtains in the bedroom • Pregnancy; because sleep (one of our main outcome measurement) can be disturbed during pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sleep timing from sleep diaries (subjective) and rest/activity profiles from actimetry (objective) and endogenous circadian phase of melatonin from saliva samples; the start of the rhythm will be measured: dim light melatonin onset (DLMO). A shift in DLMO is interpreted as a shift in the endogenous circadian pacemaker. | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep quality from subjective sleep diaries, light exposure assessed from sleep diaries (subjective) and from actimetry (objective). | — |
Countries
Netherlands
Outcome results
None listed