Plasmaceldyscrasia
Conditions
Interventions
Donor KIR-ligand mismatched haploidentical bone marow transplantation.
Sponsors
Medisch Universitair Ziekenhuis Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Patients with MM
Exclusion criteria
Exclusion criteria: - Active uncontrolled infections - Patients that are known to be HIV positive. - Patients with Donor specific HLA-antibodies - Uncontrolled CNS involvement by the malignant disease - Severe cardiovascular disease (arrhythmias requiring chronic treatment, congestive heart failure or symptomatic ischemic heart disease) - Severe pulmonary dysfunction (CTCAE grade III-IV) - Severe neurological or psychiatric disease - Significant hepatic dysfunction (serum bilirubin or transaminases >= 3 times upper limit of normal) - Significant renal dysfunction (creatinine clearance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression free survival 18 weeks after transplantation. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Response rate 2. Incidence of graft failure, engraftment and time to neutrophil and platelet recovery 3. Incidence and Severity of Acute and Chronic GVHD 4. Non-Relapse Mortality 5. Evaluation of infections after haploBMT and T cell reconstitution 6. NK cell repertoire reconstitution and maturation rates including alloreactivity 7. NK cell repertoire in the Bone Marrow before and after (6 weeks) transplantation 8. Cost calculation 9. Quality of Life | — |
Countries
Netherlands
Outcome results
None listed