Influence of renal function on the circadian variation of cardiac troponin

Influence of renal function on the circadian variation of cardiac troponin - Circadian variation of cardiac troponin in CKD

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON41818

Enrollment

Registered

2014-05-26

Start date

2014-09-09

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Kidney Disease impaired renal function

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Individuals (age >18 years) with chronic kidney disease (CKD) stage 3 (eGFR 30*59 mL/min/1.73m2) and stage 4 (eGFR 15*29 mL/min/1.73m2) without dialysis and with no evidence of active cardiac disease (abscence of: angina pectoris, cardiomyopathy and myocarditis) (age >18 years) will be recruited to participate in our study.

Exclusion criteria

Exclusion criteria: - acute myocardial infarction (AMI) in the last year. - anaemia (Hb

Design outcomes

Primary

Measure	Time frame
Concentrations of cardiac troponin T and I over 24 hours, after one week, after one month and after three months	—

Secondary

Measure	Time frame
Measures of: * Basic clinical chemistry parameters to verify a non-disturbed day-night rhythm; such as cortisol, creatine kinase and electrolyte concentrations * Basic clinical chemistry, haematological and endocrinological parameters to assess the variation of these parameters in subjects with diminished kidney function * 24 hour automatic blood pressure measurements * Albumin concentration and hematocrit values, to correct for hydration status. * Concentration of creatinine, to estimate the glomerular filtration rate. * Urine concentrations of creatinine, electrolytes and cardiac markers.	—

Measure

Time frame

Measures of: * Basic clinical chemistry parameters to verify a non-disturbed day-night rhythm; such as cortisol, creatine kinase and electrolyte concentrations * Basic clinical chemistry, haematological and endocrinological parameters to assess the variation of these parameters in subjects with diminished kidney function * 24 hour automatic blood pressure measurements * Albumin concentration and hematocrit values, to correct for hydration status. * Concentration of creatinine, to estimate the glomerular filtration rate. * Urine concentrations of creatinine, electrolytes and cardiac markers.

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Countries

Netherlands

Outcome results