wound healing
Conditions
Interventions
Interventiongroup receives 4 administrations of 2000mg ascorbic acid (20ml)
intravenously in 4 consecutive days.
Controlgroup receives 4 administrations of NaCl 0.9% (20ml) intravenously in 4
consec
Ascorbic acid
Tissue healing
Vascular surgery
Wound healing
Sponsors
Meander Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Planned open arterial revascularisation surgery on 1 or 2 legs.;Age >= 18 yrs.;Vascular disease fontaine IIb or higher.
Exclusion criteria
Exclusion criteria: Age
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in woundsurface (%) of the surgical wound 30 days after surgery by intravenous suppletion of ascorbic acid in vascular surgery, with correction for the ascorbic acid level. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Relation between the ascorbicacid bloodlevel and the reduction in wound surface area of the primary surgical wound 4 weeks post-surgery. 2. Reduction in wound surface area of a secondary wound (pre-surgical existing) 4 weeks post-surgery (corrected for baseline ascorbicacid level) 3. Decreasing the incidence of woundinfections of the surgical wound within 30 days post-surgery(corrected for baseline ascorbicacid level) 4. Reduction of hospital stay (corrected for baseline ascorbicacid level) 5. Reduction of the number of readmissions within 30 days postsurgery(corrected for baseline ascorbicacid level) 6. Reduction of the number of 'all cause complications' within 30 days postsurgery(corrected for baseline ascorbicacid level) 7. Reduction of mortality within 30 days post-surgery (corrected for baseline ascorbicacid level) 8. Reduction of the time till median wound surface area healing in case the wounds in both groups are fully closed within 30 days post-surgery. (corrected for baseline ascorbicacid level) | — |
Countries
The Netherlands
Outcome results
None listed