fysiologie van microcirculatie Microcirculation smallest vessels
Conditions
Interventions
single dose of dietary supplementation with NO3- -rich beetroot juice (100ml
~
9mmol NO3-
560mg
Beet It Nederland).
Placebo: nitrate-poor beetroot juice (100 ml
James White Drinks).
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: -healthy -non smoking -18-65 year old -informed consent
Exclusion criteria
Exclusion criteria: - Age 65 year - History of -or current cardiovascular disease - Any known haematological disorder - Any known metabolic disorder (i.e. diabetes, metabolic syndrome) - Use of antihypertensive drugs and/or thrombolytic drugs - Smoking - Absence of written informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is the change in microcirculatory profile, defined by several parameters (Total Vessel Density, Perfused Vessel Density, postcapillairy venous saturation, bloodflow and velocity, and oxygen consumption and reactivity of the microvasculature) | — |
Secondary
| Measure | Time frame |
|---|---|
| - To determine the effects of dietary nitrate on the macrocirculatory parameters; heart rate (HR) and mean arterial pressure (MAP) and diastolic and systolic pressure. - To assess the relationship between the changes in the macro- and microcirculatory parameters after dietary nitrate supplementation. - To assess the relationship between the microcirculatory profile and NO metabolism | — |
Countries
Netherlands
Outcome results
None listed