Identification of germline mutations in familial and extremely early-onset urinary bladder cancer

Identification of germline mutations in familial and extremely early-onset urinary bladder cancer - Genetics of early-onset and familial bladder cancer

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON41769

Enrollment

585

Registered

2015-07-20

Start date

2016-07-01

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

bladder cancer bladder papilloma

Interventions

None listed

Eligibility

Age

12 Years to 99 Years

Inclusion criteria

Inclusion criteria: Newly identified high-risk UBC families: - Hereditary UBC: A family with at least three first-degree relatives with UBC, or a family with two first-degree relatives with UBC with uncommon characteristics (such as young never-smoking women with high-stage disease).;Early-onset patients: - Diagnosed with bladder cancer after 01-01-1989 -

Exclusion criteria

Exclusion criteria: High-risk UBC families: - Unable to read or understand the invitation letter, information brochure and informed consent form;Early-onset patients: - Unable to read or understand the invitation letter, information brochure and informed consent form - Younger than 12 years at time of study invitation

Design outcomes

Primary

Measure	Time frame
The main study parameters are the presence of rare, novel, high-penetrance mutations predisposing for familial or early-onset bladder cancer, and second-hit (somatic) mutations (found in tumor DNA).	—

Secondary

Measure	Time frame
The secondary study parameter is information on disease characteristics (tumor stage, tumor grade).	—

Countries

Netherlands

Outcome results