Colorectal liver metastasis metastasis of gut cancer in the liver
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patient age 18 years or older Histological diagnosis of mCRC (stage IV) without options for localregional treatment Presence of liver metastases on CT scan Presence of at least one liver metastases of >20mm in diameter on the CT scan Upper part of liver with left heart ventricle in field of view Able to remain supine for 90 minutes in the PET-CT scanner Ability to give study specific written informed consent
Exclusion criteria
Exclusion criteria: Pregnant or lactating patients (positive pregnancy test) Metal implants (eg pacemakers) Body weight > 100 kg Severe claustrophobia Receiving chemotherapy less than 2 months prior to the first PET scan, except in the case of progression under chemotherapy than a 2 week interval is required.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The proportion of number of concordant lesion observed with both [18F] FLTPET and CT scans on the total number of lesions observed with the CT scan (qualitative assessment). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Measurements per lesion from full kinetic filtering model 2. Measurements per lesion from simplified models 3.Test-retest reproducibility of each quantitative assessment of tumor [18F] FLT uptake 4. Correlation of full kinetic modeling with more simplified model per lesion | — |
Countries
Netherlands
Outcome results
None listed