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Conditions
Interventions
We will employ an off-line rTMS-protocol with the intention to produce
short-term effects on the functioning of the target regions. The intervention
will consist of a standard continuous theta-burst
Sponsors
Radboud Universiteit Nijmegen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Only healthy, competent females, 18-45 years old, with normal vision or corrected-to normal vision by means of contact lenses.
Exclusion criteria
Exclusion criteria: - Serious head trauma or brain surgery - Large or ferromagnetic metal parts in the head (except for a dental wire) - Implanted cardiac pacemaker or neurostimulator - Pregnancy - Large or ferromagnetic metal parts in the body - Claustrophobia - Skin diseases at intended electrode sites - Disorders of vision (i.e., deviation from *normal or corrected-to-normal vision*) - History or current presence of any neurologic or psychiatric disease - Any prescribed medication that can alter cortical excitability (e.g. antiepileptics, tricyclic anti-depressives or benzodiazepines) or can have an influence on the participant*s vigilance or cognitive performance within two weeks prior to participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are item recognition (d-prime) performance and associative memory (% correct) performance on day 3. Specifically, we expect that application of the stimulation protocol to the somatosensory hand representational area in the critical window of cortical plasticity immediately after reactivation leads to a selective impairment for later retrieval of specifically those associations that are reactivated (compared to sham stimulation). We also aim to investigate how targeting the mPFC with the cTBS protocol after reactivation selectively influences the consolidation and eventual retrieval of those associative memories that are also schema-congruent. Specifically, we expect that application of the stimulation protocol to the medial prefrontal cortex region after reactivation leads to an impairment of subsequent recall of specifically reactivated schema-congruent associations. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary study parameters will be word recall and recognition performance on the RDM-task for both learned words as well as critical items (non-presented semantically associated lures). We expect that recall and recognition on the RDM-task will display less false memories for critical items in the group that receives stimulation to the mPFC, compared to the other groups. | — |
Countries
Netherlands
Outcome results
None listed