exposure plasticisers
Conditions
Interventions
None listed
Sponsors
Westfries Gasthuis
Eligibility
Age
2 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. uncomplicated pregnancy 2. informed written consent
Exclusion criteria
Exclusion criteria: 1. Complications during the pregnancy or delivery (serious infections, asphyxia, serious congenital malformations) 2. No written informed consent for participation 3. Underlying medical condition whereby regular interventions with medical devices is required, e.g. dialysis 4. Non-singleton pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. The ambient concentrations in the home, delivery room and operating theatre will be measured using standard dust and ambient air sampling systems. 2. The DEHP and BPA levels in the urine samples of the mothers and newborn babies, and in the amniotic fluid and meconium samples will be analysed in the laboratory of the Institute for Environmental Studies (IVM), VU University, De Boelelaan 1105, 1081 HV Amsterdam, Netherlands. 3. The samples will be collected in glass containers and the neonatal urine will be collected using a DEHP- and BPA-free urine collection bags. | — |
Secondary
| Measure | Time frame |
|---|---|
| The registration forms of the medical apparatus used during the delivery will be correlated to the DEHP and BPA exposures in the mothers and newborns. All medical devices used, including make and type, will be noted by the attending nurse. Examples include intravenous catheters, intubation and ventilation equipment, epidural catheters, breast milk expressing equipment, etc. Due to the fact that DEHP is rapidly metabolised in the human body, it is not necessary to correct for exposures prior to the time of delivery. | — |
Countries
Netherlands
Outcome results
None listed