Severe sepsis or severe blood poisoning
Conditions
Interventions
The intervention group will receive ELC within 6 hours after intubation and
start of MV. The ELC around the legs will be inflated to a pressure of 50 cmH2O
during inspiration and deflated to a press
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Age >18 years,
Exclusion criteria
Exclusion criteria: - Morbid obese defined as BMI > 35 kg/m2; - Death appearing imminent at admission (predicted in less than 24 hours) - Pregnancy - Injury or trauma of legs - Burns of surface areas of legs - Visible ulcers and known peripheral arterial insufficiency of legs;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cumulative fluid balance over first 3 days. | — |
Secondary
| Measure | Time frame |
|---|---|
| Global hemodynamic parameters (heart rate, blood pressure, central venous pressure and cardiac output),, vasopressor need, number of ventilator free days, length of stay in the ICU and in the hospital, and SOFA scores. | — |
Countries
Netherlands
Outcome results
None listed