Brain development between ages 8 and 25: A longitudinal study

Brain development between ages 8 and 25: A longitudinal study - BDC

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON41665

Enrollment

280

Registered

2010-12-17

Start date

2011-02-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

GEEN AANDOENING! gezonde hersontwikkeling: hersenfunctie, hersenstructuur en gedrag n.a.

Interventions

None listed

Eligibility

Age

2 Years to 99 Years

Inclusion criteria

Inclusion criteria: See also page 20 in the protocol 1. Healthy children, adolescents and young adults without a history of neurological disorders 2. Right-handed 3. No counter-indications for MRI 4. Native Dutch speakers

Exclusion criteria

Exclusion criteria: 1. Lefthanded 2. A history of psychiatric and/or neurological disorders 3. Counter-indications for MRI (such as metal implants, heart arrhythmia, claustrophobia, and possible pregnancy

Design outcomes

Primary

Measure	Time frame
The MRI-scans: 1. Structural MRI, to gain information on gray and white matter properties (volume, density and cortical thickness) 2. DTI, to gain specific information on white matter microstructure and fibertracking 3. Functional MRI, to gain information on task-related brain activity during cognitive and emotional decisionmaking. Pubertal assessment: 1. Participants will be asked to complete three self-report measures of pubertal maturation. The self-report scales are 1) the picture-based interview about puberty (PBIP), 2) the Tanner scale, and 3) the Pubertal Development Scale (PDS: Petersen et al., 1988 2. Participant will be asked to provide saliva and urine samples to test for testosterone, DHEA, progesterone, estradiol and luteinizing hormone (LH; the earliest hormonal marker of puberty) levels. Genes 1. Genetic information will be measured using an easy cheek swab method.	—

Measure

Time frame

The MRI-scans: 1. Structural MRI, to gain information on gray and white matter properties (volume, density and cortical thickness) 2. DTI, to gain specific information on white matter microstructure and fibertracking 3. Functional MRI, to gain information on task-related brain activity during cognitive and emotional decisionmaking. Pubertal assessment: 1. Participants will be asked to complete three self-report measures of pubertal maturation. The self-report scales are 1) the picture-based interview about puberty (PBIP), 2) the Tanner scale, and 3) the Pubertal Development Scale (PDS: Petersen et al., 1988 2. Participant will be asked to provide saliva and urine samples to test for testosterone, DHEA, progesterone, estradiol and luteinizing hormone (LH; the earliest hormonal marker of puberty) levels. Genes 1. Genetic information will be measured using an easy cheek swab method.

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Secondary

Measure	Time frame
See above	—

Countries

Netherlands

Outcome results