chronic bronchitis Chronic Obstructive Pulmonary Disease (COPD) emphysema
Conditions
Interventions
None listed
Sponsors
CIRO+, expertisecentrum voor chronisch orgaanfalen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Aged 40-85 years (COPD patiënts en controls age group 1) and aged 20-39 (controls age group 2). 2. Diagnosis of COPD according to GOLD guidelines (stage I-IV), only applicable for COPD patients. 3. Referral for assessment in CIRO+, and pulmonary rehabilitation in CIRO+ or CIRO+ rehabilitation network. 4. Subject is able to walk without walking aids. 5. Clinically stable evaluated by the physician.
Exclusion criteria
Exclusion criteria: 1. Neuromuscular co-morbidities 2. Subject is unable to walk without walking aids 3. Subject with open wounds 4. Medical history of asthma, lung cancer, sarcoidosis, tubercolosis, long fibrosis, or any other significant respiratory disease; having undergone lung surgery (e.g. lung volume reduction, lung transplantation); any clinical relevant disease which in the opinion of the investigator may influence the results of the study. 5. Other significant respiratory disease or chronic heart failure in controls.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - 6MWD - variability of Centre of Mass in medio-lateral direction | — |
Secondary
| Measure | Time frame |
|---|---|
| - Variability of Centre of Mass (COM) in anterior-posterior (COMAP) and vertical (COMV) direction - Centre of Pressure (COP) in medio-lateral, anterior-posterior and vertical direction, respectively COPML, COPAP, COPV - Average walking speed - Step length - Stride length - Cadence - Number of stops (assessed by D-flow software) - Lower-limb muscle strength and endurance (Biodex, Biodex Medical Systems Inc., New York, US) - Transcutaneous oxygen saturation during each 6MWT in hallway and on treadmill using a handheld pulse oximeter. - Borg scores of all 6MWT - Lung function using post-bronchospirometry - Resting ECG, evaluated by the physician - Body composition using DEXA - Balance using the TUG-test - 6MWD in hallway - While performing the 6MWT in the hallway and on the treadmill, the Minimod accelerometer (McRoberts, the Hague, the Netherlands; size 8.5x5.0x1.0 cm; weight 70 g) will be attached to the trunk at the height of the sacrum using an elastic belt. Matlab software (MathWorks, Eindhoven, the Netherlands) will be used to calculate step time, step length, acceleration intensity, cadence and acceleration amplitude variability. | — |
Countries
Netherlands
Outcome results
None listed