Chronic kidney disease Kidney failure
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: age 18 years or over able to give informed consent
Exclusion criteria
Exclusion criteria: - not willing to be informed about unexpected findings during the study - (possible) pregnancy or lactation - previous donor nephrectomy - known or suspected diseases or conditions that could interfere with the study - use of any prescribed medication (excl. contraceptives) and home use of NSAID*s - body mass index >30 - diagnosed hypertension or hypertension (>140/90mmHg) upon screening;For MRI scanning in general: - claustrophobia - metal implants, devices etc.: endoprosthesis, pacemaker, birth control device (IUD), neurostimulator, - - insulin pump, intra-ocular metal particles, metal heart valve, cochlear implant - previous severe allergic reaction to contrast medium (only when contrast is used, healthy subjects phase 1);For GFR measurement (applicable to healthy subjects only) - iodine allergy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Phase 1: Reproducibility of renal BOLD signal, blood flow and blood/tissue/urine fractions Phase 2: Intra individual changes in renal MRI signals (BOLD, blood flow and blood/tissue/urine fractions) and GFR and ERPF before and during reduced renal perfusion. | — |
Secondary
| Measure | Time frame |
|---|---|
| Phase 2: Change in blood pressure induced by angiotensin II | — |
Countries
Netherlands
Outcome results
None listed