Autism spectrum disorders Pervasive developmental disorders
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
2 Years to 99 Years
Inclusion criteria
Inclusion criteria: The diagnosis of ASD in the proband, according to the DSM-IV (APA 1994) or DSM-5criteria, established by an expert clinician. Proband age between 5 and 25 years. Availability of at least 1 biological parent
Exclusion criteria
Exclusion criteria: Proband younger than 5 or older than 25 years of age. Family members of the proband: no age exclusion criteria. Epilepsy and/or mental retardation are not criteria for exclusion Known genetic disorders at entry (e.g. fragile X) are not a reason for exclusion, however such conditions will be noted in the participant*s research file.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| (1) Non-synonymous single nucleotide changes in DNA coding sequence (2) Copy number variants | — |
Secondary
| Measure | Time frame |
|---|---|
| (1) Nature and severity of autistic symptoms (2) Nature and severity of co-morbid psychiatric symptoms Potential confounding factors including age, gender, years and level of education, years and level of parental education, medication use. | — |
Countries
Netherlands
Outcome results
None listed