cocaïnemisbruik en cocaïneafhankelijkheid addiction cocaine dependence
Conditions
Interventions
25 men receive 25 days of working memory training and 2400 mg N-acetylcysteine
per day
25 men receive 25 days of working memory training and placebo
Before and after this 25-day period, there is ano
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: male, 18-60 years old, using cocaine at least 4 times per maand
Exclusion criteria
Exclusion criteria: Suffering from a neurological or medical illness; lifetime history of head injury with loss of consciousness for more than 5 minutes; unstable medical illness (e.g., hypertension, diabetes, myocardial infarction); severe stomach problems or ulcers; exclusion criteria for MR imaging such as the presence of non-removable metal objects (e.g. arteriovenous clips, pacemakers) and claustrophobia interfering with MR investigation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - cocaine use - craving - working memory - glutamate concentrations in dACC and striatum | — |
Secondary
| Measure | Time frame |
|---|---|
| none | — |
Countries
Netherlands
Outcome results
None listed