executive tasks and/or information processing functioning of memory language
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Patients undergoing a scheduled renal transplantation with a live kidney donor before having started dialysis or within one year after starting dialysis and their donors. * Sufficient visual and hearing acuity * Dutch or English language fluency * Willingness to give informed consent * ABO compatible
Exclusion criteria
Exclusion criteria: * Pre-existing documented cognitive impairment * A history of psychiatric illness * Use of psychoactive substances * A history of cerebrovascular disease (either transitory ischaemic attack or cerebrovascular accident) * Brain injury * Epilepsy * Acute or chronic infections * Malignancy * Unstable coronary vascular disease * Uncontrolled hypertension * Liver disease or other metabolic disease leading to encephalopathy * Diabetes mellitus * Uncorrected anemia (Hb
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The change in mental performance in kidney recipients at twelve months after transplantation compared to pre-transplantation. | — |
Secondary
| Measure | Time frame |
|---|---|
| o The change in mental performance in kidney recipients at twelve months after transplantation compared to the change in mental performance in kidney donors. o Changes in cortical, hippocampal, temporal atrophy and global cerebral atrophy, using both visual rating scales as well as volumetric analyses. o Changes in white matter lesions using both visual rating scales as well as volumetric analyses. o Presence of microinfarctions and areas with microbleeding at baseline and occurrence of new lesions during followup. o Change in cerebral blood flow as measured by arterial spin labelling. | — |
Countries
Netherlands
Outcome results
None listed