Postprandial bile acid metabolism in insulin sensitive and insulin resistant subjects: The Bile Acid Study

Postprandial bile acid metabolism in insulin sensitive and insulin resistant subjects: The Bile Acid Study - The bile acid study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON41585

Enrollment

Registered

2012-12-19

Start date

2013-06-11

Completion date

Unknown

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diabetes mellitus glucose intolerance

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Healthy volunteers or Insulin resistant (HOMA-IR > 2.7)

Exclusion criteria

Exclusion criteria: *Use of medication that interferes with insulin metabolism (such as sulfonylureas, meglitinides, metformin, thiazolidenidiones, acarbose, dipeptidyl peptidase-4-inhibitors) or insulin. *Use of medication that interferes with BA metabolism (colesevelam, colestimide, ursodeoxycholic acid). Previous cholecystectomy Weight increase or decrease >10% in previous 3 months Alcohol use >2 units/day Pregnancy and use of oral contraceptives in females

Design outcomes

Primary

Measure	Time frame
Difference in postprandial bile acid levels in plasma, bile acid pool composition and bile acid kinetic parameters	—

Secondary

Measure	Time frame
Changes in postprandial glucose kinetics and glucoregulatory hormones, activation of TGR5 and FXR mediated pathways in muscle and fat Resting energy expenditure Gastric emptying Adherence to diet Microbiome composition	—

Countries

Netherlands

Outcome results