neurodegeneratieve of neuropsychiatrische aard bvFTD phenocopy patients
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients: - Age between 40 and 75 - Prominent behavioral changes interfering with social functioning and consisting of disinhibiton and/or apathy and/or stereotypy. - Patients* initial condition remains stable (i.e. no progression is reported one year after initial routine diagnostic workup). Control inclusion criteria: - Age between 40 and 75
Exclusion criteria
Exclusion criteria: Patient exclusion criteria: - Contraindications for MRI scanning (see appendix for full MRI contraindication screening list) - Inability to comprehend fMRI tasks - Psychiatric symptoms - Dagnosis of dementia - Acute onset of symptoms - No heteroanamnesis - History of cerebral disorders with residual symptoms - Mental retardation, developmental disorder - Past or current substance abuse Control exclusion criteria: - Contraindications for MRI scanning (see appendix for full MRI contraindication screening list) - Inability to comprehend fMRI tasks - Neurocognitive disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| * White and grey matter volumes. * White matter integrity: mean diffusivity (MD) and fractional anisotropy (FA) maps. * Brain activity: extent of fMRI activation (number and spatial distribution of significantly activated voxels). * Quantitative brain perfusion maps. | — |
Countries
Netherlands
Outcome results
None listed