brain structure cognition
Conditions
Interventions
None listed
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: General: Subjects aged 18 to 45 and subjects gave written informed consent.;MELAS patients: Confirmed carrier of the m.3243A>G mutation and mild MELAS phenotype (fatique, myopathy, mild exercise intolerance).;Diabetes type 2: Fasting blood glucose >= 7.0 mmol/l and/or used oral glucose-lowering medication or insulin.;Age, gender and level of education matched controls: Those that do not carry the m.3243A>G, the age, gender and level of eduction of the group of healthy controls should not differ significantly from the age of the group of patients
Exclusion criteria
Exclusion criteria: All groups: Contra-indications for MRI examination: 1) pacemaker, 2) neurostimulator, 3) medication pump, 4) cochlear or hearing implant, 5) tattoos or other items that cannot be removed and include metal parts, 6) metal splinter in the eye, 7) pregnancy, 8) claustrophobia, 9) brain vessel clamps, 10) denture, which contains magnets, 11) operations in the past, where metal or synthetic material is used and still were in the body; psychiatric or other disorders likely to impact on informed consent; diabetes mellitus type 1 (DM1).;MELAS patients: Other mitochondrial/neurological/psychiatric disease/syndrome other than MELAS. Severe phenotype (stroke-like lesions and severe exercise intolerance).;Age, gender and level of eduction matched controls: Any mitochondrial/neurological/psychiatric disease/syndrome.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MRI Biomarkers of brain alterations, including: • Quantitative measures (T1/T2* relaxation times), • Cerebral blood flow (arterial spin labeling, ml blood/100 g tissue/min), • Functional characteristics (in resting state or during a task), | — |
Secondary
| Measure | Time frame |
|---|---|
| Cognitive functioning z-scores based on different domains: • Memory, • Mental speed, • Attention and executive functioning, • Visual and spatial abilities | — |
Countries
Netherlands
Outcome results
None listed