Feasibility study for a novel and clinically useful MRI sequence for imaging myelin in MS patients

Feasibility study for a novel and clinically useful MRI sequence for imaging myelin in MS patients - Imaging myelin in MS patients

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON41522

Enrollment

120

Registered

2010-12-02

Start date

2011-04-26

Completion date

Unknown

Last updated

2024-11-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

loss coordination multiple sclerosis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: * Clinically definite MS (according to the subgroups) * Age between 18 - 60 years of age (to exclude age related chance of other neurological disorders) * EDSS

Exclusion criteria

Exclusion criteria: * Clinically isolated syndrome * Other neurological disorders * Claustrophobia * Foreign non MR compatible metal objects in the body * Foreign metal objects in or close to the head

Design outcomes

Primary

Measure	Time frame
Highly skilled radiologist from the VUmc will visually compare the standard diagnostic scans (a T2 weighted fast spin echo and a 3D T1 weighted scan) against the myelin water fraction images. All three types of scans will be compared to determine any additional information the myelin water fraction images may give. The healthy controls will provide a standard to judge the impact of MS on the myelin water fraction images of the patients. Any differences between lesions on the standard diagnostics images and the myelin water images will be tabulated.	—

Measure

Time frame

Highly skilled radiologist from the VUmc will visually compare the standard diagnostic scans (a T2 weighted fast spin echo and a 3D T1 weighted scan) against the myelin water fraction images. All three types of scans will be compared to determine any additional information the myelin water fraction images may give. The healthy controls will provide a standard to judge the impact of MS on the myelin water fraction images of the patients. Any differences between lesions on the standard diagnostics images and the myelin water images will be tabulated.

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Countries

Netherlands

Outcome results