Transcranial Magnetic Stimulation combined with electromyography and electroencephalography as a diagnostic and prognostic tool in Juvenile Myoclonus Epilepsy.

Transcranial Magnetic Stimulation combined with electromyography and electroencephalography as a diagnostic and prognostic tool in Juvenile Myoclonus Epilepsy. - TMS-EMG/EEG as clinical tool in JME

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON41514

Enrollment

122

Registered

2013-10-30

Start date

2014-05-27

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epilepsy Seizures

Interventions

None listed

Eligibility

Age

12 Years to 99 Years

Inclusion criteria

Inclusion criteria: In generally good health Normal cognitive functioning Speaking Dutch, English, French, German 1st epileptic seizure OR >2 years seizure free Diagnosis of JME confirmed 12 years or older;for migraine: 18 years or older Migraine with aura (3/10 attacks) diagnosed according to ICHD-III criteria One or more attacks per year

Exclusion criteria

Exclusion criteria: Use of medication with known effect on ion channel function (i.e. b-blocker) Previous head/skull surgery (ferromagnetic material) Diabetes mellitus (affects peripheral nervous system) pregnancy (alters cortical excitability) Neurological condition other than JME Treated with anti-epileptic drugs before Any neurological condition (including migraine) Any psychiatric condition 1st degree family members with epilepsy;for migraine: Use of prophylactic medication up to 4 weeks prior to measurement Use of attack medication less than 3 days prior to the measurement Headache on the day of measurement

Design outcomes

Primary

Measure	Time frame
Study parameters: change in conventional cortical excitability parameters (motor threshold, MEP (motor evoked potential) amplitude, cortical silent period, recovery curve, short and long intra-cortical inhibition, intra-cortical facilitation). Endpoints: Seizure reduction: seizure free intervals, reduction of days with myoclonus, number of generalised tonic-clonic seizures and seizure recurrence within a year (with aid of seizure diary).	—

Measure

Time frame

Study parameters: change in conventional cortical excitability parameters (motor threshold, MEP (motor evoked potential) amplitude, cortical silent period, recovery curve, short and long intra-cortical inhibition, intra-cortical facilitation). Endpoints: Seizure reduction: seizure free intervals, reduction of days with myoclonus, number of generalised tonic-clonic seizures and seizure recurrence within a year (with aid of seizure diary).

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Countries

Netherlands

Outcome results