Unraveling the molecular and Cellular muscular mechanisms associated with Aging in rotator cuff Tears of the Shoulder

Unraveling the molecular and Cellular muscular mechanisms associated with Aging in rotator cuff Tears of the Shoulder - CATS

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON41495

Enrollment

Registered

2013-08-02

Start date

2014-06-19

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

rotator cuff tear

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients undergoing MRI/CT evaluation of the shoulder. For biopsies collection, MRI/CT proven shoulder pathology for which shoulder surgery is needed. These will include, but not be limited to: - Shoulder instability (primary) - Rotator cuff tearing - Osteoarthritis - Fractures

Exclusion criteria

Exclusion criteria: - Age 80 years - No informed consent - Comorbidity: neurological disorders (stroke, M. Parkinson, dementia, muscle disease), rheumatoid arthritis, polymyalgia rheumatic, heart failure, COPD (Gold III-IV), chronic pain syndrome (fibromyalgia, complex regional pain syndrome etc) - Metabolic diseases (e.g. insuline dependent DM) - Cancer - Medication: immunosuppressive drugs (e.g. prednisone, methotrexat, biologicals (TNF-alpha antagonists etc)) - Limited access to obtain muscle biopsies due to surgical exposure.

Design outcomes

Primary

Measure	Time frame
Growth capacity, Cell fusion, microarray (RNA)	—

Secondary

Measure	Time frame
MRI/CT quantification (pathology, fatty infiltration, muscle atrophy), Clinical scores (Constant score, range of motion, muscle strength, VAS, DASH and WORC).	—

Countries

Netherlands

Outcome results