rheumatoid arthritis
Conditions
Interventions
None listed
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Men or women, * 18 years old 2. Diagnosis of rheumatoid arthritis according to the 1987 revised criteria of the American Rheumatism Association (ARA) and/or the 2010 ACR/EULAR Rheumatoid Arthritis Classification Criteria. 3. Patients with obvious clinical arthritis activity assessed by a physician, in at least 2 hand, wrist or knee joints. 4. Treatment with disease modifying anti-rheumatic drugs (DMARDS) and oral corticosteroids up to 10 mg daily is allowed. Non-steroidal anti-inflammatory drugs (NSAID) is permitted, provided that there is a stable dose for at least 1 month. Furthermore, prior or current treatment with biologics is permitted, provided that there is a stable dosing schedule for at least 3 months. 5. Patients must be able to adhere to the study appointments and other protocol requirements. 6. Patients must be capable of giving informed consent and the consent must have been obtained prior to the study related procedures.
Exclusion criteria
Exclusion criteria: 1. Use of intramuscular or intravenous corticosteroids within 4 weeks prior to screening. 2. Treatment with any investigational drug within the previous 3 months. 3. Pregnancy or breast-feeding. 4. Previous exposure to radioactivity with a yearly cumulative dose of * 5 mSv.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Standardized uptake values (SUV) in arthritic joints Target-to-background ratio (i.e uptake in arthritic joints divided by uptake in peri-articular tissue). | — |
Countries
Netherlands
Outcome results
None listed