fundamenteel onderzoek bij gezonde vrijwilligers not applicable
Conditions
Interventions
Transcranial alternating current stimulation (tACS) will be delivered by a
battery-driven constant DC current stimulator (Eldith DC Stimulator (CE 0118),
Ilmenau) using a pair of electrodes (35 cm^2
(2) Delta tACS (1 Hz, 2 mA/ 35 cm^2, 15 min)
(3) Placebo tACS (0 mA/ 35
cm^2, 15 min).
Sponsors
Radboud Universiteit Nijmegen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 18-35 Years of age, non smoking, right-handed, left dominant frontal brain activity in the beta band (20 Hz)
Exclusion criteria
Exclusion criteria: Skin disease, metal in cranium, use of psychotropic drugs, including cannabis, XTC, amphetamines and cocaine, epilepsy or family history of epilepsy, history of closed-head injury, history of neurological or psychiatric disorders, medication use (i.e., benzodiazepines, antidepressants and neuroleptica), cardiac pacemaker, electronic hearing devices, pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Beta (13-30 Hz) oscillations as being assessed by four minute background EEG recorded from 32 scalp locations according to the International 10-20 EEG System using Ag-AgCl-tipped electrodes. | — |
Secondary
| Measure | Time frame |
|---|---|
| Cerebral physiology: Motor evoked potentials to single and paired-pulse transcranial magnetic stimulation (TMS) will be used to examine brain asymmetry by measuring intracortical inhibition/facilitation of the left and right hemisphere and interhemispheric connectivity; Behavior and mood: Selective attention for emotional faces using the validated emotional Stroop task and mood using the 20-item Profile of Mood States (POMS) questionnaire. | — |
Countries
Netherlands
Outcome results
None listed