movement disorder secondary dystonia
Conditions
Interventions
All patients will be treated with DBS in the posteroventrolateral GPi.
Sponsors
Medisch Universitair Ziekenhuis Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Mental competence - Age between 18 and 65 years - A current or previous psychiatric illness that has been stable for at least 6 months - Diagnosis of TDD - TDD must be present for at least 12 months and impede physical and or social functioning - BFMDRS >8 or AIMS >16 - Pharmacological treatments for TDD had insufficient effect or could not be tolerated
Exclusion criteria
Exclusion criteria: - The patient does not fully comprehend the effects and potential side effects of brain surgery - The patient is suicidal - The patient has cognitive impairments - The patient is severely mentally ill - A neurological disease that explains the dyskinesia or dystonia - Use of recreational drugs within the last 3 months - Previous DBS or ablative stereotactic brain surgery - General contraindications for stereotactic surgery and general anaesthesia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary objective, improvement on the movement disorder rating scales. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary objectives improvement on the quality of life measured on the SF36 and the WHO-QoL including a cost effectiveness analysis, psychiatric stability as measured on the BPRS and the MADRS and cognitive effects as measured with the test battery used in the Nstaps trial. | — |
Countries
Netherlands
Outcome results
None listed