Autism Spectrum Disorder
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
2 Years to 11 Years
Inclusion criteria
Inclusion criteria: High-risk siblings: - Age between 4 months and 6 months OR younger than 11 months - Older full sibling with ASD (clinical diagnosis autism, PDD-NOS or Asperger syndrome) - At least one parent speaks Dutch to child at home (does not need to be parent*s native language);Controls: - Age between 4 months and 6 months OR younger than 11 months - Older full sibling with typical development (by parent report) - At least one parent speaks Dutch to child at home (does not need to be parent*s native language)
Exclusion criteria
Exclusion criteria: High-risk siblings: - Diagnosis of epilepsy or history of fits/convulsions - Presence of genetic syndrome (in proband or infant) clearly related to ASD (e.g. Tuberous Sclerosis, Fragile-X) - Presence of known significant uncorrected vision or hearing impairment in infant (reported to parent by a doctor or health professional) - Infant was premature (pre 36 weeks) - Infant is looked after by the state (e.g. foster care), or other situation in which neither birth parent is involved in the infant*s care. - Presence of known significant developmental or medical condition in infant likely to affect brain development or infant*s ability to participate in the study (e.g. Cerebral Palsy, Down*s syndrome, cystic fibrosis, foetal alcohol syndrome);Low-risk: - Diagnosis of epilepsy or history of fits/convulsions - Presence of known significant uncorrected vision or hearing impairment in infant (reported to parent by a doctor or health professional) - Infant was premature (pre 36 weeks) - Infant is looked after by the state (e.g. foster care), or other situation in which neither birth parent is involved in the infant*s care. - Presence of known significant developmental or medical condition in infant likely to affect brain development or infant*s ability to participate in the study (e.g. Cerebral Palsy, Down*s syndrome, cystic fibrosis) - Interested in study because parents are concerned that their infant is developing ASD, despite negative family loadings - Presence of ASD in 1st degree relatives
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main dependent measure is the diagnosis of ASD and the severity of ASD symptoms at age 36 months. The main predictive measures for cognition, eye tracking and EEG/ERP are: - Cognitive functioning (Mullen Scales of Early Learning) - Time locked voltage changes (µV) at different electrode sites (EEG) - Amplitude of event-related potentials wave to stimuli (ERPs) - Evaluation of EEG power spectrum (frequency and time frequency analysis) (EEG) - Power changes (µV2) at different electrode sites (EEG) - Oxygenated and deoxygenated hemoglobin concentration changes (NIRS) - Location of eye gaze and timing of eye movements (eye tracking) - Anticipatory eye movements (eye tracking) - Fixation duration (eye tracking) | — |
Countries
Netherlands
Outcome results
None listed