fever pyrexia
Conditions
Interventions
Patients will be allocated into two groups:
1. A control group (standard-of-care)
2. Intervention group (PCT-guided therapy)
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: fever
Exclusion criteria
Exclusion criteria: under 18 years of age. Pregnant patients. Immunocompromised patients (neutropenia, defined as an absolute neutrophil count less than 0.5x109/L, current chemotherapy, transplantation patients), predetermined illness with an expected death within 24 hours. Surgical fever, defined as fever within 72 hours post-surgery, or patients with a primary surgical diagnosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| * Number of febrile patients who are prescribed antibiotics in the ED * A composite endpoint for safety of PCT-guided therapy, defined as 30 days mortality, Intensive Care Unit (ICU) admittance, or a return visit to the ED within 14 days. * Accuracy of PCT and CRP as area under curve (AUC), compared with the diagnosis of infection by culture, polymerase chain reaction (PCR) and serology. | — |
Secondary
| Measure | Time frame |
|---|---|
| * Hospital treatment costs. (Costs of PCT testing (treatment group only), antibiotics, and other related medical consumption during admittance). * Costs of length of hospital stay (hospitalized patients) or length of ICU stay (critically ill patients). * Related medical consumption during follow-up. (General practitioner (GP) and additional hospital visits, diagnostics and medication) * Days absence from work and reduced productivity while at work. (if applicable) * Costs of extramural type and duration of antimicrobial therapy. | — |
Countries
Netherlands
Outcome results
None listed