The role of inflammatory mediators (platelet activity,the number and origin of micro particles and levels of mitochondrial DNA) in patient with acute renal transplant rejection.

The role of inflammatory mediators (platelet activity,the number and origin of micro particles and levels of mitochondrial DNA) in patient with acute renal transplant rejection. - Inflammatory mediators in acute renal transplant rejection

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON41402

Enrollment

Registered

2012-10-31

Start date

2013-01-24

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute renal transplant injury renal inflammation

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Renal transplant recipients from heart beating, non-heart-beating donors and living donors. Patients and healthy volunteers have to sign the informed consent form.

Exclusion criteria

Exclusion criteria: -

Design outcomes

Primary

Measure	Time frame
The main parameter of this study is the presence and activity of inflammatory mediators, platelet activity (measured as P-selectin positive platelets), the origin and numbers of micro particles, and levels of circulating (plasma) and local (urinary) mtDNA).	—

Secondary

Measure	Time frame
Concentrations of proinflammatory cytokines and chemokines in plasma and urine (TNF-alpha, IL-1beta, IL-6 and IL-8) and acute tubular injury markers in urine (KIM-1 and NGAL).	—

Countries

Netherlands

Outcome results