overgewicht en obesitas Overweight
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
2 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1.Healthy (self-reported) 2. Age group 1: 8-10, group 2: 13-17, group 3: 25-45 and group 4:65-75 at day 01 of the study 3. Body Mass Index (BMI): between 20 and 25 kg/m2 (normal weight adults) or 25.1 and 35 kg/m2 (overweight adults). For children and adolescents we calculated BMI ranges based on age and gender by using the growth reference data for 5-19 year olds of the World Health Organization (Butte, Garza et al. 2007). A BMI range of -1SD to +1SD in children equals approximately a BMI of 20-25 in adults; A BMI range of +1SD to +3SD in children equals approximately a BMI of 25-35.0 in adults. 4. Right-handed 5. Having given their written informed consent and in children, written informed consent from children and both parents. 6. Willing to comply with the study procedures 7. Willing to accept use of all anonymized data, including publication, and the confidential use and storage of all data 8. Willing to be informed about chance findings of pathology and approving of the disclosure of this information to the general physician (see Informed Consent)
Exclusion criteria
Exclusion criteria: 1.Smoking 2.Having a special diet (e.g. to lose weight, medically prescribed diet in the past 6 months, no meat etc) 3.Highly restraint eating (Van Strien et al., 1986). 4.Having a food allergy 5.Having gained or lost >5 kg of body weight in the past 6 months. 6.Having a history of or current alcohol consumption > 28 units per week 7.Having a history of medical or surgical events that may significantly affect the study outcome, such as metabolic or endocrine disease, or any gastro-intestinal disorder 8.Mental or physical status that is incompatible with the proper conduct of the study 9.Not having a general practitioner 10.Participation in any other clinical trial during this study. 11.Working at the Image Sciences Institute or the Radiology Department of the UMC Utrecht as employee or student. 12.MRI exclusion criteria a)Claustrophobia b)Having metal implants (i.e. pacemaker, metal joints, prostheses, etc.) or metal objects on the body which cannot be removed (i.e. piercing, hearing aid, brace, etc. c)Being pregnant. 13. Task related exclusion criteria a)Unsuccessful satiation of the participant (i.e. hungry after protein shake consumption) b) Nausea 14. Menopause (applies only to women of age group 1 (25-45 years old))
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| 1. Scores on the liking task & perceived caloric content 2. Gut hormone levels during hungry and satiated condition on several timepoints. 3. Neural activation (percentage BOLD signal change) in response the execution of a reward task. | — |
Primary
| Measure | Time frame |
|---|---|
| Neural activation (percentage BOLD signal change) induced by the presentation of pictures of food and food choice. | — |
Countries
Netherlands
Outcome results
None listed