social anxiety disorder social phobia
Conditions
Interventions
None listed
Sponsors
Universiteit Leiden
Eligibility
Age
2 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Good comprehension of Dutch language (in both speech and writing) - In good mental and physical health (e.g., appropriate physical mobility to participate in fMRI experiments). - Aged 25-55 years (adults) and 8-21years (children) - One of the target's children should be living at home with his/her biological parents - Children of the brother(s)/sister(s) of the target participant may be older than 21 years - For the target participants (those with a social anxiety disorder) 'social anxiety disorder' must be the primary classification. Comorbidity with another internalizing disorder (e.g., depression) is allowed - One of the children of the 'target participant' should show elevated levels of social anxiety (90th percentile) based on social anxiety questionnaires (please see page 16-17 research protocol)
Exclusion criteria
Exclusion criteria: For the target and target's child with social anxiety symptoms, exclusion criteria are: psychiatric disorders other than depression are specifically excluded (e.g., autism, schizophrenia). For all participants, exclusion criteria are mental and/or physical disabilities that conflict with participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main dependent variables are * Outcomes scores on the questionnaires * Physiological indices (e.g. heart rate), for example Inter-beat-interval linked to the onset of a specific event in the neurocognitive paradigm * Peak amplitude and latency of cortical event-related brain potentials. For example, P1, FRN, and P3 components of the even-related brain potential * Brain activity in pre-specified cortical regions (e.g., voxels in fMRI) averaged in block-design for pre specified (task-related) conditions * Neural network indices (e.g., graph parameters, tractography). For example, strength of connectivity between brain areas. In graph theory, functional connectivity could be indexed by the phase lag index, or the synchronization likelihood. * EEG power (e.g., alpha, theta) bands (mean power indices will be used). * Cognitive bias indices derived from the attentional paradigms. This will be indexed by the differences in reaction time. For example, longer reaction times when viewing social (threatening) vs. non-social stimuli. * Genetic information (acquired with blood samples) Control variables Gender, intelligence, and depression are used as control variables | — |
Countries
Netherlands
Outcome results
None listed